Schommers Lab

Publications

2023

  • Schommers P, Kim DS, Schlotz M, Kreer C, Eggeling R, Hake A, Stecher M, Park J, Radford CE, Dingens AS, Ercanoglu MS, Gruell H, Odidika S, Dahlhaus M, Gieselmann L, Ahmadov E, Lawong RY, Heger E, Knops E, Wyen C, Kümmerle T, Römer K, Scholten S, Wolf T, Stephan C, Suárez I, Raju N, Adhikari A, Esser S, Streeck H, Duerr R, Nanfack AJ, Zolla-Pazner S, Geldmacher C, Geisenberger O, Kroidl A, William W, Maganga L, Ntinginya NE, Georgiev IS, Vehreschild JJ, Hoelscher M, Fätkenheuer G, Lavinder JJ, Bloom JD, Seaman MS, Lehmann C, Pfeifer N, Georgiou G, Klein F.
    Dynamics and durability of HIV-1 neutralization are determined by viral replication
    Nature Medicine, 2023
  • Kreer C, Lupo C, Ercanoglu MS, Gieselmann L, Spisak N, Grossbach J, Schlotz M, Schommers P, Gruell H, Dold L, Beyer A, Nourmohammad A, Mora T, Walczak AM, Klein F.
    Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals
    Nature Communications,     2023
  • Gruell H, Schommers P.
    Advancing bnAb combinations for HIV prevention
    Lancet HIV, 2023 
  • Augustin M, Stecher M, Wüstenberg H, Di Cristanziano V, Sandaradura de Silva U, Picard LK, Pracht E, Rauschning D, Gruell H, Klein F, Wenisch C, Hallek M, Schommers P, Lehmann C.
    15-month post-COVID syndrome in outpatients: Attributes, risk factors, outcomes, and vaccination status - longitudinal, observational, case-control study
    Frontiers in Immunology, 2023
  • COVID-19 Host Genetics Initiative
    A second update on mapping the human genetic architecture of COVID-19
    Nature, 2023
  • Radford CE, Schommers P, Gieselmann L, Crawford KHD, Dadonaite B, Yu TC, Dingens AS, Overbaugh J, Klein F, Bloom JD.
    Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning
    Cell Host Microbe,     2023
  • Augustin M, Heyn F, Ullrich S, Sandaradura de Silva U, Albert MC, Linne V, Schlotz M,Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald SJ, Lehmann C.
    Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome
    Frontiers in Medicine (Lausanne),     2023
  • Malin JJ, Suárez I, Biehl LM, Schommers P, Knops E, Di Cristanziano V, Heger E, Pflieger E, Wyen C, Bettin D, Rybniker J, Fätkenheuer G, Lehmann C.
    Immune response to mRNA-based COVID-19 booster vaccination in people living with HIV
    HIV Medicine,     2023

2022

  • Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP Jr, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ.
    A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
    Science Advances, 2022
  • Gruell H, Vanshylla K, Korenkov M, Tober-Lau P, Zehner M, Münn F, Janicki H, Augustin M, Schommers P, Sander LE, Kurth F, Kreer C, Klein F
    SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns
    Cell Host Microbe, 2022
  • Degenhardt F, Ellinghaus D, Juzenas S,…, Schommers P,…, Karlsen TH, Cáceres M, Franke A.
    Detailed stratified GWAS analysis for severe COVID-19 in four European populations
    Human Molecular Genetics, 2022
  • Bannister WP, Mast TC, de Wit S, Gerstoft J, Wiese L, Milinkovic A, Hadziosmanovic V, Clarke A, Rasmussen LD, Lacombe K, Schommers P, Staub T, Zagalo A, Portu JJ, Tau L, Calmy A, Cavassini M, Gisinger M, Borodulina E, Mocroft A, Reekie J, Peters L; EuroSIDA study group.
    Changes in body mass index and clinical outcomes after initiation of contemporary antiretroviral regimens
    AIDS, 2022
  • Weber S, Kehl V, Erber J, Wagner KI, Jetzlsperger AM, Burrell T, Schober K, Schommers P, Augustin M, Crowell CS, Gerhard M, Winter C, Moosmann A, Spinner CD, Protzer U, Hoffmann D, D'Ippolito E, Busch DH.
    CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients
    PloS One, 2022
  • Tober-Lau P, Gruell H, Vanshylla K, Koch WM, Hillus D, Schommers P, Suárez I, Suttorp N, Sander LE, Klein F, Kurth F.
    Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections
    Emerging Infectious Diseases, 2022
  • Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Schommers P, Lehmann C, Kurth F, Sander LE, Klein F.
    mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant
    Nature Medicine, 2022
  • Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
    Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
    Cell Host Microbe, 2022

2021

  • Wagh K, van Gils MJ, Gristick H, Schommers P
    Editorial: Novel Concepts in Using Broadly Neutralizing Antibodies for HIV-1 Treatment and Prevention
    Frontiers in Immunology, 2021
  • Augustin M *, Schommers P*, Stecher M*, Dewald F, Gieselmann L, Gruell H, Horn C, Vanshylla K, Cristanziano VD, Osebold L, Roventa M, Riaz T, Tschernoster N, Altmueller J, Rose L, Salomon S, Priesner V, Luers JC, Albus C, Rosenkranz S, Gathof B, Fätkenheuer G, Hallek M, Klein F, Suárez I, Lehmann C.
    Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study
    Lancet Regional Health Europe, 2021
  • Hentrich M, Müller M, Wyen C, Bogner J, Thomssen H, Wasmuth JC, Wolf T, Hoffmann C*, Schommers P*.
    Characteristics and outcome of human immunodeficiency virus (HIV)-associated primary effusion lymphoma as observed in the German HIV-related lymphoma cohort study
    British Journal of Haematology, 2021
  • Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F; FinnGen; COVID-19 Host Genetics Initiative (HGI), Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales JM, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A.
    Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
    Journal of Clinical Investigation, 2021
  • COVID-19 Host Genetics Initiative.
    Mapping the human genetic architecture of COVID-19
    Nature, 2021
  • Warnat-Herresthal S*, Schultze H*, Shastry KL*, Manamohan S*, Mukherjee S*, Garg V*, Sarveswara R*, Händler K*, Pickkers P*, Aziz NA*, Ktena S*, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL.
    Swarm Learning for decentralized and confidential clinical machine learning
    Nature, 2021
  • Gieselmann L*, Kreer C*, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
    Effective high-throughput isolation of fully human antibodies targeting infectious pathogens
    Nature Protocols, 2021
  • Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
    Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans
    Cell Host Microbe, 2021
  • Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Müller RU, Augustin M, Lehmann C, Koch M, Klein F, Di Cristanziano V.
    Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG
    Microorganisms, 2021

2020

  • Stecher M*, Schommers P*, Kollan C, Stoll M, Kuhlendahl F, Stellbrink HJ, Wasmuth JC, Stephan C, Hamacher L, Lehmann C, Boesecke C, Bogner J, Esser S, Fritzsche C, Haberl A, Hoffmann C, Jensen B, Schwarze-Zander C, Platten M, Fätkenheuer G, Schmidt D, Gunsenheimer-Bartmeyer B, Vehreschild JJ; ClinSurv Study Group.
    Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017
    Infection, 2020
  • Augustin M*, Schommers P*, Suárez I*, Koehler P, Gruell H, Klein F, Maurer C, Langerbeins P, Priesner V, Schmidt-Hellerau K, Malin JJ, Stecher M, Jung N, Wiesmüller G, Meissner A, Zweigner J, Langebartels G, Kolibay F, Suárez V, Burst V, Valentin P, Schedler D, Cornely OA, Hallek M, Fätkenheuer G, Rybniker J, Lehmann C.
    Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020
    Euro Surveillance, 2020
  • Schommers P*, Gruell H*, Abernathy ME*, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F.
    Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
    Cell, 2020
  • Eberhardt KA*, Meyer-Schwickerath C*, Heger E, Knops E, Lehmann C, Rybniker J, Schommers P, Eichenauer DA, Kurth F, Ramharter M, Kaiser R, Holtick U, Klein F, Jung N, Di Cristanziano V.
    RNAemia Corresponds to Disease Severity and Antibody Response in Hospitalized COVID-19 Patients
    Viruses, 2020
  • Kreer C*, Zehner M*, Weber T, Ercanoglu MS, Gieselmann L, Rohde C, Halwe S, Korenkov M, Schommers P, Vanshylla K, Di Cristanziano V, Janicki H, Brinker R, Ashurov A, Krähling V, Kupke A, Cohen-Dvashi H, Koch M, Eckert JM, Lederer S, Pfeifer N, Wolf T, Vehreschild MJGT, Wendtner C, Diskin R, Gruell H, Becker S, Klein F.
    Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients
    Cell, 2020
  • Kreer C*, Döring M*, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
    openPrimeR for multiplex amplification of highly diverse templates
    Journal of Immunological Methods, 2020

2019

  • Ehrhardt SA*, Zehner M*, Krähling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F.
    Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV
    Nature Medicine, 2019
  • Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, Nyengaard JR, Estes JD, Abdel-Mohsen M, Østergaard L, Tolstrup M, Søgaard OS, Denton PW.
    TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
    EBioMedicine 2019
  • Schoofs T*, Barnes CO*, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ.
    Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
    Immunity, 2019

2018

  • Schommers P*, Gillor D*, Hentrich M, Wyen C, Wolf T, Oette M, Zoufaly A, Wasmuth JC, Bogner JR, Müller M, Esser S, Schleicher A, Jensen B, Stoehr A, Behrens G, Schultze A, Siehl J, Thoden J, Taylor N, Hoffmann C.
    Incidence and risk factors for relapses in HIV-associated non-Hodgkin lymphoma as observed in the German HIV-related lymphoma cohort study
    Haematologica, 2018
  • Stecher M, Schommers P, Schmidt D, Kollan C, Gunsenheimer-Bartmeyer B, Lehmann C, Platten M, Fätkenheuer G, Vehreschild JJ; ClinSurv Study Group.
    Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016
    Infection, 2018
  • Hughes RA, May MT, Tilling K, Taylor N, Wittkop L, Reiss P, Gill J, Schommers P, Costagliola D, Guest JL, Lima VD, Monforte AD, Smith C, Cavassini M, Saag M, Sterling TR, Sterne JAC.
    Long-term trends in CD4 cell counts, CD8 cell counts, and the CD4: CD8 ratio: ART Cohort Collaboration (ART-CC) Study
    AIDS, 2018

2017

  • Schommers P*, Thurau A*, Bultmann-Mellin I*, Guschlbauer M, Klatt AR, Rozman J,Klingenspor M, de Angelis MH, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ.
    Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state
    Molecular Metabolism, 2017
  • Trickey A, May MT, Schommers P, Tate J, Ingle SM, Guest JL, Gill MJ, Zangerle R, Saag M, Reiss P, Monforte AD, Johnson M, Lima VD, Sterling TR, Cavassini M,Wittkop L, Costagliola D, Sterne JAC; Antiretroviral Therapy Cohort Collaboration(ART-CC)
    CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)
    Clinical Infectious Diseases, 2017
  • Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F,Carrington M, Altfeld M.
    HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells
    Cell Host & Microbe, 2017

2016

  • Schommers, P, Martrus, G, Matschl, U, Sirignano, M, Lütgehetmann, M, Richert, L, Hope, TJ, Fätkenheuer, G, Altfeld, M.
    Changes in HIV-1 Capsid stability induced by common CTL-driven viral sequence mutations
    Journal of Virology, 2016
  • Hoffmann C*, Schommers P*, Wolf E, Müller M, Schultze A, Krznaric I, Stoehr A, Wolf T, Fäktenheuer G, Stier B, Wyen C, Hentrich M.
    CD4+ and CD8+ T-cell kinetics in aviremic HIV-infected patients developing Hodgkin or non-Hodgkin lymphoma
    AIDS, 2016
  • Wang Q, De Luca A, Smith C, Zangerle R, Sambatakou H, Bonnet F, Smit C, Schommers P, Thornton A, Berenguer J, Peters L, Spagnuolo V, Ammassari A, Antinori A, Roldan EQ, Mussini C, Miro JM, Konopnicki D, Fehr J, Campbell MA, Termote M, Bucher HC; Hepatitis Coinfection and Non Hodgkin Lymphoma project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord.
    Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients: A Cohort Study
    Annals of Internal Medicine, 2016
  • Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M.
    Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
    Diabetes, 2016

2015

  • Schommers P*, Hentrich M*, Hoffmann C, Gillor D, Zoufaly A, Jensen B, Bogner JR, Thoden J, Wasmuth JC, Wolf T, Oette M, Müller M, Esser S, Fätkenheuer G, Wyen C
    Survival with AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma Cohort
    British Journal of Haematology, 2015

2014

  • Franko A*, von Kleist-Retzow JC*, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ.
    Liver adapts mitochondrial function to insulin resistant and diabetic states in mice
    Journal of Hepatology , 2014
  • Xicoy B*, Ribera JM*, Müller M, García O, Hoffmann C, Oriol A, Hentrich M, Grande C, Wasmuth JC, Esteve J, van Lunzen J, Del Potro E, Knechten H, Brunet S,  Mayr C, Escoda L, Schommers P, Alonso N, Vall-Llovera F, Pérez M, Morgades M, González J, Fernández A, Thoden J, Gökbuget N, Hoelzer D, Fätkenheuer G, Wyen C;  for the PETHEMA Group and German HIV Lymphoma Cohort.
    Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients
    Leukemia and Lymphoma , 2014

2013

  • Schommers P*, Wyen C*, Hentrich M, Gillor D, Zoufaly A, Jensen B, Bogner JR,Thoden J, Wasmuth JC, Fätkenheuer G, Hoffmann C.
    Poor outcome of HIV-infected patients with plasmablastic lymphoma: results from the German AIDS-related lymphoma cohort study
    AIDS , 2013
  • Re A, Cattaneo C, Skert C, Balsalobre P, Michieli M, Bower M, Ferreri AJ, Hentrich M, Ribera JM, Allione B, Schommers P, Montoto S, Almici C, Ferremi P, Mazzucato M, Gattillo S, Casari S, Spina M, Diez-Martin JL, Tirelli U, Rossi G; Cooperative European Group on AIDS and Tumors.
    Stem cell mobilization in HIV seropositive patients with lymphoma
    Haematologica , 2013
Schommers Lab

PD Dr. Dr. Philipp Schommers, MD/PhD
Center for Molecular Medicine Cologne CMMC
University of Cologne
Robert-Koch-Str. 21
50931 Cologne
Germany

Phone +49 221 478 89659
philipp.schommers@uk-koeln.de
www.schommers-lab.cmmc-uni-koeln.de

Imprint
Privacy Policy
Center for molecular medicine Cologne
University of Cologne University of Cologne University Hospital of Cologne